Innovation in Diuretic Therapy

Diuretic therapy and diuretic resistance in cardiac failure.

s 40 venous capacitance within a few minutes before any with oedema is defined as a clinical state where the braking phenomenon occurs before the therapeutic measurable increase in urinary output can be seen [1,2]. This rapid haemodynamic improvement is goal is reached. thought to be due to the release of vasodilatory prostaglandins [3]. However, in a study in patients with severe oedema, i.v. ...

[Diuretic-based therapy].

Diuretics are pharmacological agents that increase natriuresis through inhibition of tubular re-absorption of sodium. The mechanisms and site of this inhibition differ with each drug class, accounting for their additive effects on natriuresis increase and their hydroelectrolytic side effects. The response to a given diuretic dose depends on the diuretic concentration on the urine at its action ...

Long-term Oral Diuretic Therapy

Hypertensive patients were treated with either chlorthalidone or frusemide for periods of two to four months. Reduction in blood pressure was seen with chlorthalidone but not with frusemide. This hypotensive effect appeared to be independent of the natriuretic effect. A significant reduction in total exchangeable potassium (KE) was seen with both agents, but no patient showed adverse symptoms o...

Pendrin-A New Target for Diuretic Therapy?

The nephrotic syndrome complicating mercurial diuretic therapy.